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Sunday, July 15, 2018
09:00 - 12:15 | Concurrent Short Courses 1 and 2 Short Course 1: Model Systems and Methods for Assessing Uptake and Efflux of Small Molecules View the Short Course 1 Lecture Abstracts Co-chairs: Yurong Lai, Gilead Sciences; and Sonia de Morais, SDM BioPharma
09:00 - 09:45 Novel in vitro Models to Study Transporters Yurong Lai, Gilead Sciences
09:45 - 10:30 Animal Models for Drug Transporters Dan Bow, AbbVie, Inc.
10:45 - 11:30 PET Imaging to Understand Hepatobiliary Transporters Yuichi Sugiyama, RIKEN
11:30 - 12:15 Probe Drugs for Clinical Transporter DDI Evaluation Maciej Zamek-Gliszczynski, GSK
09:00 - 09:50 Introduction to the Fundamentals of Induction Michael Sinz, Bristol-Myers Squibb
09:50 - 10:40 Nuclear receptor phosphorylation as a Novel Drug Target for induction Masahiko Negishi, National Institute of Environmental Health Sciences, NIH
10:55 - 11:35 Technical Aspects Related to in vitro Induction Assessment Steve Ferguson, National Institute of Environmental Health Sciences
11:35 - 12:15 In vitro Data Fitting and Interpretation Jane Kenny, Genentech
12:15 - 13:30 | Short Course Attendee Lunch Break 13:30 - 16:45/17:00 | Concurrent Short Courses 3 and 4 Short Course 3: In silico Modeling of in vitro Metabolism, Transport, and Toxicity Data View the Short Course 3 Lecture Abstracts Chair: Iain Gardner, Certara
13:30 - 13:45 Why is Modeling of in vitro Data Important? Iain Gardner, Certara
13:45 - 14:35 Experimental Approaches to Understand Intracellular Based Drug Bioavailability Per Artursson, Uppsala University
14:35 - 15:15 In silico Approaches to Modeling Transporter Data Manthena Varma, Pfizer Inc.
15:30 - 16:00 Mechanistic Modeling of in vitro Assays to Improve in vitro/in vivo Extrapolation Grace Fraczkiewicz, Simulations Plus
16:00 - 16:30 Simultaneous Modeling of Metabolism, Competitive and Mechanism Based Inhibition Howard Burt, Certara
16:30 - 17:00 Virtual Cell Models to Predict Binding and Distribution of Chemicals in in vitro Toxicity Assays Ciaran Fisher, Certara